PCSK9 inhibitors are the second most used family of drugs for lowering cholesterol after statins. These extremely efficient medications aid in the removal of excess cholesterol from the blood, but unlike statins, which can be taken orally, PCSK9 inhibitors can only be given intravenously, posing limitations to their administration. An oral small-molecule medication that decreases PCSK9 levels and cholesterol in animal models by 70 per cent is now described in a new study by researchers at University Hospitals (UH) and Case Western Reserve University School of Medicine. The research, which was published in Cell Reports, reveals a new way to control cholesterol that could possibly have an effect on cancer treatments. LDL receptors, which are found on the surface of liver cells and remove cholesterol from the blood, are essential for controlling serum cholesterol levels. By designating them for destruction, PCSK9 in the bloodstream regulates the number of LDL receptors. The quantity of LDL receptors that remove cholesterol is thereby increased by PCSK9 inhibitors.
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